ea0037gp.26.04 | Thyroid – hypothyroidism | ECE2015
Ramos Helton Estrela
, de Oliveira Cerqueira Taise Lima
, Ramos Yane Rocha
, Leite Paula
, Santos Jailciele
, San Martin Daniel
, Costa Anabel Goes
, Fernandes Vladimir
, Strappa Giorgia
, de Jesus Mariana Souza
, Amorim Tatiana
, Ladeia Ana Marice
Context: Several specific transcriptional factors, in view of their important role in thyroid organogenesis and thyroid specific gene expression, would be strong candidate genes for the etiology of TD. The homeobox transcription factor NKX2.5 was thought to be only required for the organogenesis of the heart tube. However, NKX2.5−/− embryos also exhibited a smaller outgrowing thyroid bud. Indeed, several loss ...